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NEW QUESTION # 23
Which method remains the "gold standard" for ANA detection?
- A. Enzyme Immunoasay (ELISA)
- B. Lateral Flow Immunoassay
- C. Radioimmunoassay (RIA)
- D. Slide-based immunofluorescent assay (IFA) or Colorzyme
NEW QUESTION # 24
Though it may not be required, TDM should still be used to confirm adequate dosing. Genotyping does not make TDM redundant.
A PM will metabolize the drug more slowly and therefore will need lower doses. CYP2D6 metabolizes many different drugs; it is not associated with just one class of drugs. Anytime a drug is taken that competes for the same metabolizing enzyme as another drug, there is potential for the concentrations of both drugs to be increased.
A patient has been characterized as a CYP2D6 poor metabolizer (PM) after genotyping. Which of the following statements is not true?
- A. CYP2D6 metabolizes many drugs, and so attention must be given to the doses of drugs from different classes.
- B. The patient is less likely to require therapeutic drug monitoring (TDM) since the genotype is known.
- C. The patient will likely need lower doses of CYP2D6-metabolized drugs.
NEW QUESTION # 25
Coumarin derivatives inhibit the vitamin K dependent Factors (II, VII, X) which can be measured with the PT and monitored frequently with the INR assay.
Warfarin-based (coumarin derivative) oral anti-coagulant therapy is commonly monitored with :
- A. Thrombin time
- B. PT/INR
- C. APTT and PT
- D. APTT
NEW QUESTION # 26